The city leaders signed a book of condolence at Manchester Central Library and lay a wreath in St Ann's Square in tribute to Queen Elizabeth II.
Lord Mayor of Manchester Councillor Donna Ludford said: "The city of Manchester shares the nation's sorrow at the passing of Her Majesty Queen Elizabeth II, but also the sense of gratitude for her long reign and service to the nation. On behalf of all Mancunians, I send condolences to the Royal Family for their loss as we prepare to extend our support to the next monarch."
Councillor Bev Craig, Leader of Manchester City Council said: "Queen Elizabeth II has been the national figurehead for as long as most of us can remember, a symbol of continuity and stability through changing and sometimes turbulent times. We remember her visits to the city over the years, both on happy occasions such as when she opened the 2002 Commonwealth Games, and celebrated her Diamond Jubilee in 2012, and darker moments such as when she helped comfort young people injured in the 22 May 2017 terror attack at Manchester Arena. She served the nation with incredible dedication and dignity. On behalf of all Mancunians, we share the nation's sorrow and extend our condolences to the Royal Family and the whole country."