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- Union Baptist, Queen's Park, Rochdale Road: Harpurhey
- Union Street (Ebenezer) Methodist New Connexion: Oldham
- Union Street Wesleyan: Bury
- Union Street Wesleyan: Rochdale
- Union Workhouse, Farnworth: Bolton
- Unitarian (Ebenezer), King Edward Street/Back Street: Macclesfield
- Unitarian: Croft
- Unitarian: Sale
- United Methodist Church: Over Peover
- United Methodist: Littleborough
- United Reformed Church- See Gatley, Congregational (above): Gatley
- Unsworth South Wesleyan, Hillock Lane: Unsworth
- Upper Brook Street Unitarian (formerly Manchester, Mosley Street Presbyterian): Chorlton-on-Medlock
- Upper Brook Street Unitarian- See Chorlton-on-Medlock, Upper Brook Street Unitarian: Manchester City Centre
- Upper Moss Lane Primitive Methodist: Hulme
- Urmston Cemetery- See Manchester, New Synagogue, Jewish: Urmston
- Urmston Primitive Methodist, Higher Road: Urmston
- Urmston Wesleyan, George Street: Urmston
- Victoria Hall Wesleyan, Daniel Street: Ancoats
- Victoria Wesleyan, Bolton Road (formerly Moss Lane): Pendlebury